Hi,
As my wife's brother would say, "This is just one darned fool's opinion." For me, I would have the top section (where you have the one drawer) open. Then drawers below. The reasons:
The top of the cabinet would hold things I am very apt to want in the night such as Kleenex, note pad, pencil, water in a short, fat, glass with a heavy bottom to prevent mid-night klutzy movement spills, cell phone with ringer turned off (it is there in case of need for emergency outgoing telephone call) and a clock). I have not had an emergency incoming telephone call for at least 65 years. I have had a lot of wrong numbers placed by drunks, etc. Therefore ringer is turned off.
The open section, just below the top would hold the next most important items that might be used in the night. This would keep them within easy reach yet leave the top basically clear to reach priority items in the night.
The drawers would contain books, my next to most recent glasses, a couple WW magazines, a clipboard and pencil,. It might also hold a different size pillow, in case I want to exchange in the night.
Enjoy,
Jim