Hi Larry... there are two methods I have used...
The classic approach is to have a frame between each drawer (also holds the dust shield). I make the sides about 1/16 inch thicker than the front, which is finish wood, so the drawer doesn't scratch the finish wood. Build the frame with 1/32 or so above, and 1/32 or so below the front of the frame - just enough to keep the drawer bottom (and top) away from the front piece.
That classic approach doesn't keep the drawer centered, so I am moving towards plan B - side runners mounted on the front and back of the carcase (so that it straddles floating panels on the sides, for example). Those runners are just under 3/4 inch high (to fit in a 3/4 inch dado in the sides of the drawers. The dado is about 1/4 inch deep in the drawer (thus requiring drawer sides 5/8 " or more thick. The runners are about 3/8 inch thick - to hold the drawer centered and provide clearance on each side.
If you have an overlay drawer, the drawer front determines the depth the drawer closes... the runner only has to be close. If you have an inset drawer front, you can get fancy with a stopped dado, and let the end of the side runner stop the drawer. Easiest way I have found is to trim the end of the runner to adjust the drawer depth. See
http://www.plesums.com/wood/bedroom/lingeriechest.html for an example of the inset drawer front with the side runners... in that case, I played with the dovetails so the runner was in a wide pin. In the chest in my shop now, I purchased the drawers unassembled, cut the dado in the sides, assembled the drawers, cut the dado through the back on the shaper, and squared off the stopped dado on the front with hand chisels.